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LOCATION:Online / Moscow\, st. Ordzhonikidze 3\, Hall 2 (room 708)
DESCRIPTION:This lecture highlights the development of a methodology that provides a repertoire of synthetic tools for the achievement of N-alkylated\, macrocyclic peptides\, including inhibitors of protein-protein interactions\, antibacterial and anticancer peptides. The lecture also reports on the determination of the three-dimensional structures of the macrocyclic peptide serving a mimetics of protein secondary structures. This includes a detailed NMR study (i.e.\, TOCSY\, COSY\, HSQC HMBC\, and ROESY) combined with molecular dynamic simulation.
DTSTART:20231004T163000Z
DTEND:20231004T180000Z
SUMMARY:Lecture “Multicomponent Synthesis of Macrocyclic and Stapled Peptides”
URL;VALUE=URI:/media/events/lecture-multicomponent-synthesis-of-macrocyclic-and-stapled-peptides/
DTSTAMP:20250429T005152Z
UID:680ff878642bf
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